COVID-19 has amplified FOOD, ENERGY, AND WATER (FEW) insecurities across the world and disproportionately impacted Indigenous communities. In the United States, COVID-19 is rampant within the Navajo Nation, the largest tribe in the United States, where the rate of poverty (38%) is more than twice that of the state of Arizona (15%). Navajo tribal officials cite the lack of healthy foods and running water as reasons for the prolific virus transmission, resulting in one of the highest COVID-19 infection rates in the United States. The Navajo Nation is a rural food desert, with only 13 grocery stores for a population of nearly 200,000 tribal citizens spread across 27,000 square miles of remote terrain (population density is 8 per square mile, on average). Comorbidities such as diabetes and cancer are prevalent owing to environmental exposure from abandoned mines. Native Americans have the highest rate of diabetes of any U.S. ethnic group, and arsenic-contaminated waters on tribal lands, including the Navajo Nation, increase the risk of diabetes, chronic kidney disease, and cardiovascular disease. Furthermore, nearly 40% of remote Diné (Navajo) homes lack electricity, and more than 30% lack running water. The Diné haul water from potable and non-potable sources 5–50 miles away, incurring an enormous expense of $13.30 per 100 gallons. These and other challenges make it difficult for Diné communities to respond to and recover from perturbations such as pandemics and disasters.